Associate Professor, ESPCI - ParisTech (www.espci.fr)
Research
and development in
data analysis, pattern recognition and machine learning. My background
in both scientific
research in
machine learning algorithms and biomedical
problematics provides me with a special
qualification
to solve problems in this cross fields area.
I’m now heading the Signal Processing the LIRYC institute headed by
Pr. Haissaguerre in Bordeaux, France. The main topic of research is the
analysis of ECG and EGM signals to help in the understanding of atrial
and ventricular diseases.
H. Cochet, R. Dubois, F.
Sacher, N. Derval, M. Sermesant, M. Hocini, M. Montaudon, M.
Haïssaguerre, F. Laurent, and P. Jaïs, "Cardiac Arrythmias: Multimodal
Assessment Integrating Body Surface ECG Mapping into Cardiac Imaging,"
Radiology, vol. in press, 2013
A. J. Shah, M. Hocini, O. Xhaet, P. Pascale, L. Roten, S. B.
Wilton, N. Linton, D. Scherr, S. Miyazaki, A. S. Jadidi, X. Liu, A.
Forclaz, I. Nault, L. Rivard, M. E. Pedersen, N. Derval, F. Sacher, S.
Knecht, P. Jais, R. Dubois, S.
Eliautou, R. Bokan, M. Strom, C. Ramanathan, I. Cakulev, J. Sahadevan,
B. Lindsay, A. L. Waldo, and M. Haissaguerre, "Validation of novel
3-dimensional electrocardiographic mapping of atrial tachycardias by
invasive mapping and ablation: a multicenter study," Journal of the
American College of Cardiology, vol. 62, pp. 889-97, Sep 3 2013.
M. Haissaguerre, M. Hocini, A. J. Shah, N. Derval, F. Sacher, P.
Jais, R. Dubois, "Noninvasive
Panoramic Mapping of Human Atrial Fibrillation Mechanisms: A
Feasibility Report", Journal of cardiovascular electrophysiology, vol.
24(6), pp. 711-717, 2013
P. Milpied,R.
Dubois, P. Roussel, C. Henry, and G. Dreyfus, "Arrhythmia
Discrimination in Implantable Cardioverter Defibrillators using Support
Vector Machines applied to a New Representation of Electrograms",
Biomedical Engineering, IEEE Transactions on, vol. 58, pp. 1797-1803,
2011.PDF
F. Extramiana, R.
Dubois, M. Vaglio, P. Roussel, G.
Dreyfus, F. Badilini, A. Leenhardt, and P. Maison-Blanche, "The time
course of new T-wave ECG descriptors following single and double dose
administration of Sotalol in healthy subjects", Annals of Noninvasive
Electrocardiology, Ann Noninvasive Electrocardiol, vol. 15, pp. 26-35,
Jan 2010. PDF
X. Johnson, G. Vandystadt, S. Bujaldon, F. A. Wollman, R. Dubois
, P. Roussel, J. Alric, and D. Beal, "A new setup for in vivo
fluorescence imaging of photosynthetic activity," Photosynth Res., vol.
102, pp. 85-93, 2009. PDF
F. Badilini, M. Vaglio,
R. Dubois , P. Roussel, N. Sarapa, I. Denjoy, F.
Extramiana, and P.
Maison-Blanche, "Automatic analysis of cardiac repolarization
morphology using Gaussian mesa function modeling", J Electrocardiol,
vol. 41, pp. 588-94, Nov-Dec 2008. PDF
Y. Takahashi, M. D. O'Neill, M. Hocini, R. Dubois , S.
Matsuo, S. Knecht, S. Mahapatra, K.-T. Lim, P. Jais, A. Jonsson, F.
Sacher, P. Sanders, T. Rostock, P. Bordachar, J. Clementy, G. J. Klein,
and M. Haissaguerre, "Characterization of Electrograms Associated With
Termination of Chronic Atrial Fibrillation by Catheter Ablation",
Journal of the American College of Cardiology, vol. 51, pp. 1003-1010,
2008. PDF
F. Extramiana, A. Haggui, P. Maison-Blanche,R. Dubois, S.
Takatsuki, P. Beaufils, and A. Leenhardt, "T-wave morphology parameters
based on principal component analysis reproducibility and dependence on
T-offset position," Annals of Noninvasive Electrocardiology, vol. 12,
pp. 354-363, 2007. PDF
R. Dubois,
P.
Maison-Blanche, B. Quenet and G. Dreyfus, "Automatic ECG wave
extraction in long-term recordings using Gaussian mesa function models
and nonlinear probability estimators", Computer Methods and Programs in
Biomedicine, vol. 88(3), pp. 217-233, 2007. PDF
F. Vialatte, C. Martin,
R. Dubois,
B. Quenet, R. Gervais, and G. Dreyfus, "A machine learning approach to
the analysis of time-frequency maps, and its application to neural
dynamics", Neural Networks, vol. 20(2), pp. 194-209, 2007. PDF
P. Sanders, C. J. Nalliah, R.
Dubois,
Y. Takahashi, M. Hocini, M. Rotter, T. Rostock, F. Sacher, A. Jonsson,
L. F. Hsu, P. Jaïs, and M. Haïssaguerre, "Frequency
Mapping
of the Pulmonary Veins in Paroxysmal versus Permanent Atrial
Fibrillation", Journal of Cardiovascular Electrophysiology,
vol. 17, pp. 965-972, 2006. PDF
Y. Takahashi, P. Sanders, P. Jais, M. Hocini, R. Dubois,
M. Rotter, T. Rostock, C. J. Nalliah, F. Sacher, J. Clementy, and M.
Haissaguerre, "Organization of frequency spectra of atrial
fibrillation: relevance to radiofrequency catheter ablation", J
Cardiovasc Electrophysiol, vol. 17, pp. 382-8, 2006. PDF
R. Dubois,
B. Quenet, Y.
Faisandier, and G. Dreyfus, "Building meaningful representations for
nonlinear modeling of 1D- and 2D-signals: applications to biomedical
signals", Neurocomputing, vol. 69, pp. 2180 – 2192,
2006. PDF
H. Stoppiglia, G. Dreyfus, R.
Dubois,
and Y. Oussar, "Ranking a Random Feature for Variable and Feature
Selection", Journal of Machine Learning Research, vol. 3, pp.
1399-1414, 2003. PDF
B. Quenet, R.
Dubois, S.
Sirapian, G. Dreyfus, and D. Horn, "Modelling Spatiotemporal Olfactory
Data in Two Steps From Binary to Hodgkin-Huxley Neurones", BioSystems,
vol. 67, pp. 203-211, 2002.PDF
B. Quenet, D. Horn, G. Dreyfus, and R. Dubois, "Temporal
Coding in an Olfactory Oscillatory Model", Neurocomputing, vol. 38-40,
pp. 831-836, 2001. PDF
Conferences with procedings:
N. Zemzemi, R. Dubois, Y.
Coudière, O. Bernus, and M. Haissaguerre, "A Machine Learning
Regularization of the Inverse Problem in Electrocardiography Imaging,"
in Computing in Cardiology (CinC), Zaragoza, Spain, 2013, p. 1135. PDF
C. Cappelaere, R. Dubois,
P. Roussel, O. Baumann, A. Amblard, and G. Dreyfus, "Towards the
Selection of Patients requiring ICD Implantation by Automatic
Classification from Holter Monitoring Indices," in Computing in
Cardiology (CinC), Zaragoza, Spain, 2013, p. 1095. PDF
A. Quotb, G. Attuel, C. Pomier, Y. Komatsu, P. Jais, M. Hocini,
M. Haissaguerre, and R. Dubois,
"New Method of Assessing Cycle Lengths in Human Atrial Fibrillation,"
in Computing in Cardiology (CinC), Zaragoza, Spain, 2013, p. 1059. PDF
R. D. Walton, O. Bernus, and R.
Dubois,
"A novel approach for deriving global activation maps from non-averaged
cardiac optical signals," Conference proceedings : ... Annual
International Conference of the IEEE Engineering in Medicine and
Biology Society. IEEE Engineering in Medicine and Biology Society.
Conference, vol. 2013, pp. 1772-1775, Jul 2013. PDF
Y. Tian, B. Denby, I. Ahriz, P. Roussel, R. Dubois,
and G. Dreyfus, "Practical Indoor Localization using Ambient
RFPractical Indoor Localization using Ambient RF", presented at the
I2MTC 2013, Minneapolis, 2013.
R. Dubois, S. Labarthe,
Y. Coudière, M. Hocini and M.
Haissaguerre, "Global and Directional Activation Maps for Cardiac
Mapping in Electrophysiology", IEEE Proc. Computers in Cardiology, vol.
39, 349-352, 2012. PDF
R. Dubois, F. Extramiana,
I. Denjoy, P. Maison-Blanche, M.Vaglio,
P. Roussel, F. Babilini, A. Leenhardt "A Machine Learning Approach for
LQT1 vs LQT2 Discrimination", IEEE Proc. Computers in Cardiology, vol.
39, 437-440, 2012. PDF
O. Pont, H. Yahia, R. Dubois,
M. Haissaguerre, "A
Singularity-analysis Approach to characterize Epicardial Electric
Potential", IEEE Proc. Computers in Cardiology, vol. 39, 725-729, 2012.PDF
N. Zemzemi, S. Labarthe, R.
Dubois, Y. Coudière, " From Body
Surface potential to activation maps on the Atria: A machine learning
technique", IEEE Proc. Computers in Cardiology, vol. 39, 125-128, 2012. PDF
A. J. Shah, R. Dubois,
S. Miyazaki, A. S. Jadidi, D. Scherr, S.
B. Wilton, L. Roten, P. Pascale, M. Pedersen, N. Derval, S. Knecht, F.
Sacher, P. Jais, S. Narayan, M. Hocini, and M. Haissaguerre,
"Pathogenesis of AF: Impact on intracardiac signals," in Engineering in
Medicine and Biology Society, EMBC, 2011 Annual International
Conference of the IEEE, 2011, pp. 5523-5526.
P. Milpied, R. Dubois,
P. Roussel, C. Henry, and G. Dreyfus,
"Morphological stability of bipolar and unipolar endocardial
electrograms", IEEE Proc. Computers in Cardiology, vol. 37, pp.
733-736, 2010
I. Ahriz, B. Denby, G. Dreyfus, and R. Dubois, "The ARPEGEO
Project: A New Look at Cellular RSSI Fingerprints for Localization”,
IEEE 21st International Symposium on Personal, Indoor and Mobile Radio
Communications Workshops (PIMRC Workshops), 2010.
P. Milpied, R.
Dubois, P. Roussel, C. Henry, and G. Dreyfus,
"Morphological stability of bipolar and unipolar endocardial
electrograms", in Computers in Cardiology, 2010, 2010, pp. 733-736. PDF
R. Dubois,
P. Roussel, M. Hocini, F. Sacher, M. Haïssaguerre, and G.
Dreyfus, "A Wavelet Transform for Atrial Fibrillation Cycle Length
Measurements", IEEE Proc. Computers in Cardiology, vol. 36, pp.
501-504, 2009. PDF
R. Dubois,
P. Roussel, M. Vaglio, F. Extramiana, F. Badilini, P. Maison-Blanche,
and G. Dreyfus, "Efficient Modeling of ECG Waves for Morphology
Tracking", IEEE Proc. Computers in Cardiology, vol. 36, pp. 313-316,
2009. PDF
P. Bouchet,
R. Dubois, C. Henry, P. Roussel, and G. Dreyfus, "Spatial
Projection of Tachycardia Electrograms for Morphology Discrimination in
Implantable Cardioverter Defibrillator," IEEE Proc. Computers in
Cardiology, vol. 36, p. 9:12, 2009. PDF
M. Pernot, E. Macé,
R. Dubois, M. Couade, M. Fink, and M. Tanter, "Mapping
Myocardial Elasticity Changes after RF-Ablation Using Supersonic Shear
Imaging", IEEE Proc. Computers in Cardiology, vol. 36, pp. 793-796,
2009. PDF
Conferences:
M. Haissaguerre, R. Dubois,
A. Shah, K. Ramoul, Y. Komatsu, M.
Daly, S. Zellerhoff, A. Denis, N. Derval, F. Sacher, L. Jesel, O.
Bernus, P. Jais, and M. Hocini, "Targeted Ablation Of Persistent Af
Guided By Noninvasive Panoramic Af Mapping," presented at the HRS,
Denver, 2013
H. Cochet, R. Dubois, K.
Ramoul, A. Shah, Y.
Komatsu, G. Attuel, O. Bernus, A. Denis, M. Daly, L. Jesel, S.
Zellerhoff, J. Relan, M. Sermesant, N. Ayache, S. Eliautou, F. Sacher,
M. Montaudon, F. Laurent, M. Hocini, P. Jais, and M. Haissaguerre,
"Relationship Between Electrical Rotor Location and Atrial Fibrosis in
Persistent Atrial Fibrillation: A Combined Body Surface Mapping and MRI
Study," presented at the HRS, Denver, 2013
A. Shah, M. Hocini, R. Dubois,
S. Zellerhoff, K.
Ramoul, A. Denis, Y. Komatsu, M. Daly, F. Sacher, N. Derval, S.
Eliautou, C. Dumas, O. Bernus, P. Jais, and M. Haissaguerre, "Regional
Distribution of Rotors and Focal sources in Human AF depend on type and
duration of arrhythmia : Non Invasive Study," presented at the HRS,
Denver, 2013.
M. Hocini, R. Dubois, A.
Shah, K. Ramoul, M.
Daly, Y. Komatsu, A. Denis, S. Zellerhoff, F. Sacher, N. Derval, S.
Eliautou, O. Bernus, P. Jais, and M. Haissaguerre, "Noninvasive
Real-Time Panoramic Mapping of Clinical Ventricular Fibrillation:
Insights into Mechanisms," presented at the HRS, Denver, 2013
S. Zellerhoff, M. Hocini, R. Dubois, A. Shah, K.
Ramoul, Y. Komatsu, A. Denis, M. Daly, S. Amaroui, L. Jesel, F. Sacher,
N. Derval, S. Eliautou, C. Dumas, O. Bernus, P. Jais, and M.
Haissaguerre, "Mechanisms Driving Paroxysmal AF Displayed by
Noninvasive Panoramic Imaging," presented at the HRS, Denver, 2013.
R. Dubois, "Les
partenariats Public/Privé pour la recherche", presented at Journée
TransBiomed, Bordeaux France, 2013
R. Dubois, "Deciphering
body surface data reveals moving rotors in atrial fibrillation",
presented at Rhythm, Marseille France, 2013
R. Dubois, "Noninvasive
panoramic mapping to target ablations of paroxysmal and persistent AF",
presented at Rhythm, Marseille France, 2013
R. Dubois, "AF Mapping,
New strategies", presented at Alliance 2013, Boston Scientific,
Bordeaux France, 2013
R. Dubois, "La
cartographie non invasive du cœur en fibrillation", presented at
Journée SFR TecSan, Bordeaux France, 2012
R. Dubois, "AF Mapping,
New strategies", presented at Alliance 2012, Boston Scientific,
Bordeaux
France, 2012
R. Dubois, "Enjeux et
avenir du traitement du signal en fibrillation auriculaire", presented
at la Journée GDR-STIC santé, Paris, 2011
F. Extramiana, I. Denjoy, P. Maison-Blanche, M. Vaglio, P.
Roussel, F. Badilini, A. Leenhardt, and R. Dubois,
"LQT1 vs. LQT2 ECG phenotype adjudication: how does a machine learning
classifier perform against Cardiology Experts?" presented at Heart
Rhythm Boston, 2012.
G. Attuel, T. Desplantez, R.
Dubois,
M. Haïssaguerre, "Intermittency in atrial fibrillation, modelization
and phenomenology", presented at Journée de la Matière Condensée 13,
Montpellier, 2012
B. D. Lindsay, R. Dubois,
A. Shah, C. Ramanathan, S. Zuckerman, M. Strom, B. George, N. Varma, M.
Hocini, P. Jais, and M. Haïssaguerre, "Novel Directional Activation Map
Using Local Propagation Between Adjacent Electrograms" presented at the
Heart Rhythm Society, San Fransisco, 2011.
B. D. Lindsay, C. Ramanathan, S. Zuckerman, M. Strom, B. George, R. Dubois,
and N. Varma, "Accurate Noninvasive 3D Electrocardiographic Mapping of
Focal and Macroreentrant Atrial Tachycardia," presented at the Heart
Rhythm Society, San Fransisco, 2011.
P. Milpied, R.
Dubois,
P. Roussel, C. Henry, and G. Dreyfus, "Arrhytmia
Classification Using Spatial Projection of Tachycardia Electrograms
(SPOT)," presented at the CardioStim, Nice, 2010.
B. Degand, P. Milpied, R.
Dubois,
C. Henry, A. Kobeissi, and G.
Dreyfus, "Atrial Activity Extraction in Single-Chamber Implantable
Defibrillators," presented at the Cardiostim, Nice, 2010.
F. Extramiana,
R. Dubois, M. Vaglio, P. Roussel, G. Dreyfus, F. Badilini,
A. Leenhardt, and P. Maison-Blanche, "Evolution dans le temps des
nouveaux descripteurs ECG de l’onde T après adminis- tration
d’une dose unique et d’une double dose de sotalol
chez des sujets sains
The time course of new T-wave ECG descriptors following single and
double dose administration of Sotalol in healthy subjects," in
Journée de la Société Francaise de
Cardiologie, Paris, 2010.
P. Bouchet,
R. Dubois
, P. Henry, P. Roussel, et al., "Machine learning for shock decision in
implanted defibrillators", in Machine Learning Workshop, Clearwater,
Utah, 2009.
J. Alric, X. Johnson, G. Vandystadt, D. Beal,
R. Dubois,
and P. Roussel, "Imagerie de fluorescence appliquée
à
l'étude in vivo de l'activité
photosynthétique",
in Biophysique XXIe congrès, EBSA, 2008
A. Haggui, F. Extramiana, P. Maison-Blanche, R. Dubois,
J. Seitz, P. Milliez, B. Cauchemez, P. Beaufils, and A. Leenhardt,
"Stabilité dans le temps des paramètres de
l’onde T évalués par analyse en
composante principale", in Journée de la
Société Francaise de Cardiologie, Paris, 2006.
C. Nalliah, P. Sanders, Y. Takahashi, R. Dubois,
M. Hocini, M. Rotter, T. Rostock, P. Jaïs, L. Hsu, F. Sacher,
J.
Clementy, and M. Haïssaguerre, "Role of the Pulmonary Veins in
Paroxysmal and Chronic Atrial Fibriallation", presented at Heart
Rhythm, 2005.
R. Dubois,
B. Quenet,
Y. Faisandier, and G. Dreyfus, "Modeling Beats with Bumps", presented
at Machine Learning Workshop, Snowbird, Utah, 2003.
B. Quenet, D. Horn, R.
Dubois,
S. Sirapian, and G. Dreyfus, "Dynamic Neural Filter of Hodgkin-Huxley
Units", presented at Machine Learning Workshop, Snowbird, Utah, 2002.
B. Quenet, D. Horn, G. Dreyfus, and R. Dubois, "Temporal
coding in an olfactory oscillatory model", presented at Computational
Neuroscience, Bruges, 2000.
PhD thesis:
R. Dubois,
"Application
des nouvelles méthodes d'apprentissage à la
détection précoce d'anomalie en
électrocardiographie", in Laboratoire Electronique.
Paris-France: ESPCI, january 2004, examining board : G. Dreyfus, P.
Maison-Blanche, B. Quenet, M. Samuelides, Y. Faisandier, P. Gallinari
and P. Mabo,
avalaible from http://pastel.paristech.org/bib/archive/00000571/
Patents:
R. Dubois, C. Ramanathan
and G. Attuel, "Phase Mapping From Non-Invasive Data", date de dépôt
21/09/2012, US Provisional 61/704,227
R. Dubois, C. Ramanathan,
H. Woldinger, P. Roussel and B. George, "System and methods for
computing activation maps", date de dépôt 16/09/2011, PCT International
Application No. US2011/051954
R. Dubois and B. George,
"Signal Averaging ", date de dépôt 4 mai 2012, PCT International
Application No. US2012/36543
T. Hueber, B. Denby, R.
Dubois,
P. Roussel, and G. Dreyfus, "Dispositif de Reconstitution de la Parole
par Sondage Ultrasonore de l'Appareil Phonatoire," EP/US Patent, 2010.
P. Bouchet, R.
Dubois,
G. Dreyfus, and C. Henry, "Défibrillateur/cardioverteur
implantable simple chambre avec détection de
l'activité auriculaire par la sonde monocorps," FR/EP
Patent, FR0958898, 2009.
P. Bouchet,R.
Dubois,C.
Henry, G. Dreyfus, R. Dal Molin, and J. El Arab, "Dispositif
médical actif comprenant des moyens perfectionnés
de discrimination entre tachycardies d'origine ventriculaire et
tachycardies d'origine supraventriculaire," EP/US Patent, FR2105843,
2009.
R. Dubois,
M. Mashimo, S. Fanier, D. MacAdam, M. Haissaguerre,
T. Collins, and D. He, "Systeme de detection et de cartographie de la
longueur du cycle de fibrillation auriculaire (AFCL)
à haute densité",
in INPI. US/EU, WO2005115232, 2005.
R. Dubois,
B. Quenet,
and Y. Faisandier, "Dispositif d'analyse d'un signal, notamment d'un
signal physiologique tel qu'un signal ECG", EP/US, FR2847361, 2004.
2012: Habilitation à Diriger des Recherches (HDR), Université
Pierre et Marie Curie, Paris 6.
2000-jan.2004: PhD in signal
processing applied to
electrocardiology, ESPCI www.neurones.espci.fr
and ELA Medical www.sorin.com,
France: Early anomaly detection in long term ECG recordings by new
learning algorithms. Main research subject: machine
learning,
neural networks, signal processing, optimization,
classification.
1999-2000: MS, electronics and instrumentation, UPMC,
Paris
France.
1997-2000: Electronic engineer, ISEP (Institut
Supérieur d’Electronique de Paris), www.isep.fr,
France.
WORK EXPERIENCE :
Professional
experience
Since 2012: Team manager of the Signal Processing team in LIRYC,
in Bordeaux, France.
Since 2008: Consultant in Signal Processing
Since 2008: Associate Professor in SIGMA laboratory in
ESPCI-ParisTech, Paris, France
2007: Assistant Professor in Electronic
laboratory in ESPCI-ParisTech, Paris, France
2006: Postdoctoral researcher Temporal
model of the olfactory
pathway, SOMA (CNRS UMR 7084), UMR
1272 Physiologie de l'Insecte
Feb.-May 2004: Engineer, ELA Medical Group,
knowledge transfert of my PhD work.
2004: Digital and
analog hardware design and simulation with Altera Stratix, MicroChip,
Motorola.
2001-2004: Lecturer in
digital electronics and control processing, École
Supérieure de Physique Chimie Industrielle (ESPCI, www.espci.fr)
2000: Training period at ESPCI Electronics laboratory: Temporal coding in
an olfactory oscillatory model. Neural network
applied in modelling biological unit.
1999: Hardware design with
DSP
SKILLS IN ENGINEERING
AND
COMPUTER SCIENCE:
Several years of experience in machine learning, neural
networks and signal processing,
Experience in digital hardware design and simulation,
High-level language: Matlab, C++/C.
Assembly programming of Pic, DSP, Motorola 68HC11, 680x0
